A Few Hotfixes to Consider…
UPDATED: June 2013
I decided to collect my own short list of hotfixes for that I have recommended for an Exchange 2010/Windows 2008 R2 environment.
NOTE: This does not include security hotfixes (WSUS) and is NOT an official list of hotfixes or build recommendation - this is my list of hotfixes that I have recommended for newly deployed Exchange environments as a means to prevent known issues from occurring.
Exchange 2010 Hotfixes
Exchange 2010 Service Pack 3 – https://support.microsoft.com/kb/2808208
KB2803727 Update Rollup1 for Exchange Server 2010 Service Pack 3 - https://support.microsoft.com/kb/2803727
Office 2010 Hotfixes
Office 2010 Service Pack 1 - https://support.microsoft.com/kb/2460049
KB2597090 Description of the Outlook 2010 update: February 2013 - https://support.microsoft.com/kb/2597090
KB2553391 Description of the Outlook 2010 hotfix package: December 11, 2012 - https://support.microsoft.com/kb/2553391
KB2832226 Office 2010 cumulative update for April 2013 - https://support.microsoft.com/kb/2832226
Office 2013 Hotfixes
KB2738013 Description of the Outlook 2013 Update: April 2013 - https://support.microsoft.com/kb/2738013
Office for Mac 2011 Hotfixes
KB2830450 Description of the Microsoft Office for Mac 2011 14.3.4 Update - https://support.microsoft.com/kb/2830450
Base Windows 2008 R2 SP1 Hotfix
KB 2775511 – An Enterprise Hotfix rollup for Windows Server 208 R2 SP1 – https://support.microsoft.com/kb/2775511
Windows 2008 R2 Post-SP1 Hotfixes
KB2754704 https://support.microsoft.com/kb/2754704 -- MPIO
KB2471472 https://support.microsoft.com/kb/2471472 -- NDIS
KB2769369 https://support.microsoft.com/kb/2769369 -- WIN32SPL
KB2494016 https://support.microsoft.com/kb/2494016 -- CSVFILTER
KB2578113 https://support.microsoft.com/kb/2578113 -- CLUSRES
KB2614892 https://support.microsoft.com/kb/2614892 -- MOUNTMGR
KB2536275 https://support.microsoft.com/kb/2536275 -- SYS
KB2619234 https://support.microsoft.com/kb/2619234 -- RPCHTTP
KB2724197 https://support.microsoft.com/kb/2724197 -- Kernel
KB2779069 https://support.microsoft.com/kb/2779069 -- CLUSSVC
KB2699780 https://support.microsoft.com/kb/2699780 -- Registry
* Updated from previous hotfix notification release
Lync Server 2010 Hotfixes
Updates Resource Center for Lync - https://technet.microsoft.com/en-us/lync/gg131945
NOTE: If you cannot download the hotfix from the KB, then first, determine if you really need that hotfix and if so, consider contacting MSFT support for that build or look for another, related hotfix with similar files and build.
Have Fun...
Doug