KB: Mouse may become unresponsive after you launch an App-V application

When you launch a process that is virtualized through Microsoft Application Virtualization version 4.5, version 4.6, or version 5.0 (App-V 4.5, App-V 4.6 or App-V 5.0) on a touchscreen-enabled device, the mouse pointer may become unresponsive. If you exit either the App-V application process or the wisptis.exe process, you’ll find that the mouse starts to work again.

Note that this also affects RDS/terminal servers if the Desktop Experience is enabled (that is, if the default server setting is not enabled).

This occurs because in some cases, App-V creates a second instance of the wisptis.exe process as part of the application launch. This may create a conflict between the wisptis.exe process that's already running (because the system is touchscreen) and the new wisptis.exe process that was triggered by the application launch. By exiting either the App-V application process or the wisptis.exe process, this conflict is removed.

For complete details as well as a couple different options for a resolution, please see the following:

KB2987845 - Mouse may become unresponsive after you launch an App-V application (https://support.microsoft.com/en-us/kb/2987845)

J.C. Hornbeck | Solution Asset PM | Microsoft GBS Management and Security Division

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ConfigMgr 2012 R2