Isa Server 2006 SP1, 10061 connection refused, the server you are trying to access refused the connection

This is an interesting scenario in our social forum on which i answered on a connectivity issue.. Please have a look

https://social.technet.microsoft.com/Forums/en-US/Forefrontedgegeneral/thread/41ae945f-2d06-48a1-936d-032d1a6b43cf/#24e9c456-2684-4c88-ba4b-289a0596980b