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Troubleshooting the Forefront TMG Installation Error: "A computer restart is required. You must restart this computer before installing Forefront TMG."

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Take the backup of the Registry before making following change:

Resolution

1- Navigate to HKLM\SYSTEM\CurrentControlSet\Control\Session Manager.
2- Delete the PendingFileRenameOperations multi-string key.
3- Try to run the setup wizard again.