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VSTO: Unable to run project in debug mode

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If The Enhanced Mitigation Experience Toolkit (EMET) 4.1 or later is installed, it will prevent debugging any Microsoft Office Addin. You may not receive a message.

  1. Open “EMET GUI” from the start menu and click “Apps”
  2. Uncheck columns under the listing for the Microsoft Office product that you have created a VSTO for.

 

References:
https://code.msdn.microsoft.com/Excel-2010-Favorites-Ribbon-7dc841b8