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SharePoint Troubleshooting: Object reference not set to an instance of an object in SharePoint

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Error message

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Object Reference not set to an instance of an object.

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IISreset

1- First of all, open PowerShell as an administrator 

2-  In PowerShell, write the following script  "iisreset"  

If this will not resolve your problem check the following things.

IISManager

1- Check in IISManager that SharePoint Webservices default is running.

or

2- Check the Application Pool that "SharePointTokenServiceApplication" is running.

or

3-  Go to Central Admin -> Manage Service Application -> Delete the User Profile Service.