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Customer was using Biztalk 2013 WCF Oracle Adapter to Insert messages into Oracle Database. The host Instance would crash and we would get error “System.NullReferenceException: Object reference no set to an instance of an object”.
After we took a WCF trace we found that the real error was "Unable to load OraMTS".
Resolution:
After some research we found that this error can occur if the Ambient Transaction property on the Port Configuration is checked. Disabling it fixed the issue.