you should follow the responsive (dynamic) design suggestions:
https://learn.microsoft.com/en-us/windows/apps/design/layout/responsive-design
https://learn.microsoft.com/en-us/windows/apps/design/layout/layouts-with-xaml
note: if you did not start with fluid and responsive design, you may need major refactoring. Responsive design means designing from the start how to display on different screen and font sizes. In general you can never use absolute coordinates. My guess is even on your dev box, if you changed to large fonts it looks terrible.