Hello RedasK ,
Welcome to Microsoft Q&A Platform.
The error you're encountering is due to connectivity issues between your API Management (APIM) instance and the management API when deployed in a Virtual Network (VNet). To resolve it, ensure that your VNet is correctly configured with no network security group (NSG) or firewall rules blocking traffic on port 3443. Review the guidance on inbound connectivity to the management endpoint and check the APIM network status for any known outages. Verify DNS resolution, routing, and VNet peering to ensure proper communication.
If the issue persist, could you please provide the Resource ID of the Azure API Management? This will allow us to check the logs from our end to better understand the root cause of the issue and to provide an appropriate solution.