@Alejandro Miranda, Thanks for posting in Q&A. From your description, I find the registry key you mentioned determine whether to disable Microsoft Defender Antivirus. By default, Microsoft Defender Antivirus automatically turns itself off when it detects another antivirus program on the device. I notice we have other Antivirus uninstalled. It seems the registry has not been changed to 0.
As you mentioned, the registry on both active and disabled device are the same. That sounds strange.
But this is a very related reason. I still suggest change the registry key value to 0 manually on these affected devices to see if the result will be different.
However, if the issue still persists, please open case with Microsoft Defender for Endpoint support to look into the issue.
https://learn.microsoft.com/en-us/defender-endpoint/contact-support
Thanks for your understanding.
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