Hi @Maarten Eestermans
Looks like the issue is more related to your Hotmail account, please kindly understand that the Outlook tag here we mainly focus on general issues about Outlook desktop client. It's suggested that you could post your case in dedicated forum for Hotmail for more professional advice.
According to the error code, the recipient's domain is @hotmail.com or @outlook.com and it wasn't found by SMTP address lookup.<SMTP Address>.
For more information, see Fix email delivery issues for error code 550 5.1.10 in Exchange Online.
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