Hi @Marco vanW
If your app is only granted one type of permission, such as Graph API, then "https://graph.microsoft.com/Mail.Send" and "Mail.Send" are no different, and both point to the same thing.
However, if your app is also granted other types of permissions, such as Graph API and Outlook REST API, then using the full URL format ("https://graph.microsoft.com/Mail.Send") is necessary because it will explicitly specify the type of API you are using during authentication.
Hope this helps.
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