Hi @Bill Line
Currently, there is no relevant setting that fully achieves your needs. OneDrive is designed as a tool can sync files on different devices, not a simple cloud backup tool.
One idea: Enable the Files On-Demand feature via group policy, and then run script for files that already exist locally, and files opened later (Online-only file will be download to your device when you open it.) to free up space.
Here is a thread that users shared their scripts to free up space: https://www.reddit.com/r/SCCM/comments/aev7le/force_users_onedrive_to_free_up_space_with/
Or if you want to restrict the IP addresses that can access OneDrive, you may allow access only from IP addresses that your organization owns via "Network Location" in Access control in the SharePoint admin center.
But if you want to get the assistance from Intune, you may post a new thread with "Microsoft Intune" tag in Q&A. Thanks for your understandings.
Hope the information could be helpful.
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