Hi @joomla3597 , you should be able to use File Integrity Monitoring for this:
https://learn.microsoft.com/en-us/azure/defender-for-cloud/file-integrity-monitoring-overview
Microsoft Defender configurations, including exclusions, are often stored in specific files. However, many settings are stored in the Windows Registry.
Common registry keys related to Microsoft Defender exclusions include:
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HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows Defender\Exclusions\Paths
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HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender\Exclusions\Paths
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HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows Defender\Exclusions\Extensions
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HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender\Exclusions\Extension
You can add these to your FIM monitoring list.
Please let me know if you have any questions and I can help you further.
If this answer helps you please mark "Accept Answer" so other users can reference it.
Thank you,
James