SMTP Receive Error 421 Every 30 Seconds

Anon4343 471 Reputation points
2024-08-20T13:22:29.0933333+00:00

Our SMTP receive log shows an error every thirty seconds. SMTP traffic appears to be flowing fine from on-premise to O365/Exchange Online, but some users periodically report the following error:

the server response was: 4.7.0 Temporary server error. Please try again later. PRX5.

SMTP Receive Error Log:

2024-08-08T12:54:03.845Z,,08DCA9486495F762,0,127.0.0.1:25,127.0.0.1:43100,+,,
2024-08-08T12:54:03.845Z,,08DCA9486495F762,1,127.0.0.1:25,127.0.0.1:43100,>,421 4.3.2 Service not available,
2024-08-08T12:54:03.845Z,,08DCA9486495F762,2,127.0.0.1:25,127.0.0.1:43100,-,,Local

I have searched the web and found that this type of error could be caused by a misconfiguration where SMTP emails are not received or sent at all. However, SMTP traffic is flowing as expected. Could there be a secondary listener that needs configuring? Any suggestions for resolving this issue would be appreciated.

Microsoft Exchange Online
Exchange Server
Exchange Server
A family of Microsoft client/server messaging and collaboration software.
1,267 questions
Microsoft Exchange Hybrid Management
Microsoft Exchange Hybrid Management
Microsoft Exchange: Microsoft messaging and collaboration software.Hybrid Management: Organizing, handling, directing or controlling hybrid deployments.
2,076 questions
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Accepted answer
  1. Bruce Jing-MSFT 4,190 Reputation points Microsoft Vendor
    2024-09-09T08:27:29.0433333+00:00

    Hi,@Anon4343

    M365 backend team can assist with an on-prem hybrid Exchange Server.

    Here's how to contact the M365 team:

    User's image

    https://support.microsoft.com/en-us/topic/contact-microsoft-office-support-fd6bb40e-75b7-6f43-d6f9-c13d10850e77

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3 additional answers

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  1. Bruce Jing-MSFT 4,190 Reputation points Microsoft Vendor
    2024-08-21T05:10:58.5433333+00:00

    Hi,@Anon4343

    Thanks for posting your question in the Microsoft Q&A forum.

    To fix this issue, you can be done in 2 steps.

    Step 1: Add a custom receive connector to Office 365 IP for Port 25.

    Step 2: Bind the SSL Certificate to three receive connectors: default, default frontend, above-mentioned custom receive connector.


  2. Anon4343 471 Reputation points
    2024-09-03T17:54:48.4166667+00:00
    1. it does. The error message provided in the initial posting repeats throughout the day.
    2. We believe it's causing a periodic failure. When it does so, the sending application will not retry.

  3. Anon4343 471 Reputation points
    2024-09-16T17:19:53.5633333+00:00

    We determined that if you disable the default Frontend receive connector for security reasons, you need to create a new receive connector for the server to use.

    1. Create a new receive connector
      1. Name: <Server name> - Loopback
      2. Type: Frontend Transport
      3. Authentication: Transport Layer Security (TLS)
      4. Permission Groups: Exchange servers
      5. Remote network settings: 127.0.0.1 ; <Server IP Address>
      6. Network adapter bindings: IPv4 25
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