Hi @Mike Elias1 , thanks for posting in our Q&A forum.
Have you tried the Parameters option -AutoReplyState Enabled? Example as follows:
Set-MailboxAutoReplyConfiguration -Identity tony@contoso.com -AutoReplyState Enabled -ExternalMessage "External auto-reply message." -ExternalAudience All
If the answer is helpful, please click "Accept Answer" and kindly upvote it. If you have extra questions about this answer, please click "Comment".
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.