Hi @Cory Williams,
SharePoint is always installed on the boot drive - typically C. There should be lot of things that you should be considering if you really want to have SharePoint in a different drive:
- SharePoint Logs - Even if you point SharePoint to be installed on a different drive, it manages to create
C:\Program Files\Common Files\Microsoft Shared\Web Server Extensions\14 folders
- the 14 hive for storing important information including Logs. - Dependencies - SharePoint is dependent with a mix of technologies like IIS and SQL server, where in IIS gets loaded by default to the boot drive usually C, which would have the Inetpub folders and so on.
Finally, I would prefer SharePoint installation to be on the default C drive to make it easier.
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