@Jay Tee, Thanks for posting in Q&A. Based on my researching; to disable JavaScript on Adobe Reader DC, we can add the following registry key.
reg add "HKLM\SOFTWARE\Policies\Adobe\Acrobat Reader\DC\FeatureLockDown" /v bDisableJavaScript /t REG_DWORD /d 00000001 /f
You can firstly test on one device to see if it can work. If it works, then we can deploy via PowerShell Script to add and set this registry key. Here is a link with examples for your reference:
https://scloud.work/registry-key-with-intune/
Note: None-Microsoft link, just for the reference.
Hope the above information help.
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