Hello
Thank you for posting in Microsoft Community.
When you apply Software Restriction Policies in Active Directory through Group Policy and block .exe files, it does affect remote installation of software from third-party tools such as ManageEngine Desktop Central. Here is a detailed explanation of how the policy interacts with your system and affects software installation.
How Software Restriction Policies Work:
Software Restriction Policies allow administrators to define execution rules for applications based on file path, hash value, or digital signature. Once this policy is applied, it can block the execution of certain types of files such as .exe, .bat, .cmd, etc.
If you block .exe files globally (or based on a specific path), this will block the execution of all .exe files on the system unless they are explicitly allowed through exception rules (for example, through hash value or path rules).
I hope the above information is helpful to you.
Best regards
Runjie Zhai