Hi @Richard Roati ,
Hope everything is going well.
1,Please check your group policy to see if there are any Software Restriction Policies or APPlocker policies. The group policies will win over the client settings.
System administrator has set policies to prevent this installation
2,Or could be some new security software with new settings set in place and it may have mess up the permission or the ccmcache folder being restricted. Have you look in the logs, for example AppEnforce.log, AppIntentEval.log and SettingsAgent.log? Also, for testing software deployments it's always a good practice to do it as available and monitor the logs as you initiate the download/install.
3,Are the devices co-managed by SCCM and Intune? If yes, please also check the MDM settings.
Similar thread for your reference: Insufficient Permissions for Software Installation
Please note: The links are not from Microsoft, just for your reference.
4,Do you have multiple users logged in to the devices? If yes, ensure there's only the one user logged in to the device and see if the issue persists.
Hope it helps. Have a nice day!
Best regards,
Simon
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