Hi, @Bernard Kiss
Thank you for posting in Microsoft Q&A forum.
Microsoft Defender for Endpoint requires some level of connectivity to function properly, even when managed through System Center. For devices without direct internet access, a proxy solution is recommended to facilitate communication with the Defender cloud services. This means that while you can manage Defender through System Center, the endpoints must still have some form of connectivity, either directly or through a proxy, to ensure they can communicate with the necessary services.
In a completely offline environment, you may face challenges as Defender for Endpoint does not support endpoints without direct or proxied connectivity to the Defender cloud services. Therefore, if your system is completely offline, it may not be feasible to use Defender for Endpoint effectively.
For your references:
STEP 1: Configure your network environment to ensure connectivity with Defender for Endpoint service
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