Hello Ben, Welcome to MS Q&A
Yes, after the Active Directory (AD) integration and once the NTFS/Share permissions are properly configured, you can remove the on-premises AD storage account object that is synchronizing to the Microsoft Entra tenant. However, ensure that all necessary permissions and access configurations are in place before doing so to avoid any disruption in access.
References:
- Configure a cloud trust between on premises AD DS and Microsoft Entra ID for accessing Azure Files
- Preparing users and groups for Azure Information Protection
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Thanks,
Deepanshu