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List of URLs related to the BizTalk Performance Issues

Identifying Performance Bottlenecks
https://msdn.microsoft.com/en-us/library/aa578679.aspx

Threads, DB sessions, and throttling
https://biztalkperformance.members.winisp.net/BlogPages/MaxWorkerThreads.htm

The number of running orchestrations increases and then remains constant after you reach the thread pool limit, and orchestration execution time may increase in BizTalk Server
https://support.microsoft.com/kb/900455

Configuration Parameters that Affect Adapter Performance
https://msdn.microsoft.com/en-us/library/aa561380.aspx

Suspended Messages are Included in the Message Count in Database Throttling Threshold
https://msdn.microsoft.com/en-us/library/aa577623.aspx

MSBTS_HostSetting.ProcessMemoryThreshold Property (WMI)
https://msdn.microsoft.com/en-us/library/aa559112.aspx

How to Configure the DTA Purge and Archive Job
https://msdn.microsoft.com/en-us/library/aa558715.aspx