Cumulative update package 4 for BizTalk Server 2006 R2 Service Pack 1
This cumulative update for Microsoft BizTalk Server 2006 R2 Service Pack 1 (SP1) contains hotfixes for the Microsoft BizTalk Server 2006 R2 issues that were fixed after the release of BizTalk Server 2006 R2 SP1.https://support.microsoft.com/kb/2682056/en-us